Increased efficacy of biologics following inhibition of autophagy in A549 lung cancer cells in bimodal treatment of doxorubicin and SAR405-loaded chitosan nanoparticles
This study introduces a dual approach to enhance doxorubicin efficacy and inhibit autophagy using a nano-mediated delivery system. Autophagic inhibition is achieved by enhancing SAR405 cellular uptake through SAR405-loaded chitosan nanoparticles. The synthesized nanoparticles are then characterized for hydrodynamic diameter, polydispersity, encapsulation, and drug loading efficiencies.